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Critical Reagents: Strategic Planning, Thoughtful Selection, and the Role of Expert Partnership in Assay Success
What determines whether a PK assay succeeds often happens before development ever begins. This article from Immunologix Laboratories, co-authored with Dr. Liz Culyba of the Critical Reagents Group, examines how anti-idiotypic antibody selection, Fc format, affinity, and capture-detection pairing define assay performance, and what rigorous critical reagent planning looks like in practice. Download to explore the science behind getting reagent strategy right from the start.
A Single Low-Affinity Clone: The Downstream Consequences of Early Reagent Decisions in PK Bioanalysis
Introduction Rescue projects rarely arrive with a single, obvious point of failure. More often, the root cause traces back to an early decision that seemed reasonable at the time, one that compounds through development and validation and produces failures that become increasingly difficult to resolve. In this case, a PK assay had been developed for…